Hi Niels,
going MIDI (and using opto decoupling) is a cool, easy and pragmatic solution!
As Andy wrote, i did a few local measurements with all devices i had available out of curiosity, because i also sometimes experienced ground hums between some synths and my mixer and i was interested!
Basically, i cannot reproduce your problem, i can see a minor bit of digital noise introduced to the eurorack system, when using my PC instead of my Laptop to power the SEQ/Eurorack modules over USB, but it is perfectly acceptable and there is no ground hum problem, scoped waveforms from multiple measurements are available, if requested :).
This post by Graham Hinton seems to be a really good reference regarding the ground hum problem in general, he is very nicely explaining what’s going on and how you could address it:
https://www.muffwiggler.com/forum/viewtopic.php?t=102801#p1429534
In my own words (i may be wrong scientifically with some terms, as i am not an EE :)): when you experience ground hums, that is probably due to a different ground potential, e.g. between Eurorack PSU and PC PSU -or- one or both of those PSUs themselves being noisy, e.g. not being properly filtered. So, for example, if in one unit we have some unfiltered AC mains or switching regulator ripple being introduced, it will interfere with the other PSU over long and imperfect ground connections between those PSUs, over the PC<->SEQ<->Eurorack wiring, which is going over a long distance and many connection points, i.e. starting with the flying busboard wiring in your eurorack, the DB25-cable, the ribbon wires in the v4+, the USB cable and the wiring in your PC/PSU.
Graham also explains, how different potential can exist, even if all affected PSUs are of high quality and are well filtered. It occurs, if the two independent rails draw unequal currents (statically or dynamically).
Graham suggests to tackle the problem at its roots and run ground bonding wires between all affected PSU chassis/0V. Note, that also your mixer/powered amp/powered studio monitor elements might play a role in the audible ground hum noise and might benefit from proper external grounding too. Often, that step is not necessary, as the AC mains wire ground connection is completely sufficient, but sometimes it might be helpful.
Also note, that the AC mains cable ground connection should always stay in place for safety reasons, be very careful with ground lifters! But, if you create your own improved “studio ground”, that will basically circumvent any suboptimal ground connections and should help a lot. This method could also be employed, when you experience ground hums with other audio gear, e.g. between a synth and your studio mixer. That is also why you will sometimes find external “ground” connection points on some studio gear, for example i’ve got an audio patchbay with an external “ground hook” - adding proper grounding there makes a lot of sense, as it will affect all connected sound sources/synthesizers.
Have a good upcoming weekend and best regards!
Peter