Ever wondered, WHY you have 2 same type of opamps, but signals are wired to differend pins (besides of power)?! :o OPA2604 and NE5532 are DUAL OPAMPs, so there are 2 separate OPAMP circuits inside. Those OPAMP symbols marked U1 are build around one IC and same goes to U2.
You better believe me  : and do the next version with only 2 IC’s, ok
(Yeah, sorry.. It’s good to exercise some schematic reading.. sometimes it get’s really cryptic, when some logic chip is marked somewhere in the schematic, but its gate symbols are spread around)
Also, I’d like to add that in my board creation process, I usually break circuit in smaller subsets in my mind, then place IC’s first, and then rest of the components.
And when routing, power goes first, and then “troublesome” signals (long traces/ with crossings).
Bye, Moebius
(<opinion> p.s. Autorouters just give you a looong coffee break, before you can start working</opinion>
My main concern is I have got pin 5 of the IC’s to earth but in the schematic http://synapsysllc.com/guitarpreamp.htm it has a “+” next to pin 5 although they run to earth…
OPAMPs have 2 inputs: inverting and non-inverting.
Those OPAMP stages, with signal connected to minus (input) and plus (input) grounded are configured as inverting amplifiers. So, there’s nothing to worry about. If you want to dig deeper in theory check:
I had a quick peek at your V3 design, and didn’t see any errors. I think that you could get rid off jumper wires altogether, with some modifications. Like rotating cap C2 90 degrees, and running trace (C-D) under it and manipulating orientation of battery connections.