Moebius,
I guess you mean it’s already screwed up, so more serial data muxed in won’t make it much worse >:(?
Man, I really hate to burst your bubble on this, but if you haven’t got any prior experience with them, or haven’t been reading a lot of web info, try not to get overly “high hopes” on that MTPAV. The Micro Express parallel was one of my biggest gear disappointments in memory, and MOTU unfortunately seems to have decided on a “unified” driver version for their USB and COM port MIDI devices, neither of which appear to be 100% trustworthy, and the driver is already a couple years old, despite all the problems and complaints. FWIW, I think I’ve seen less complaints on the MTP’s than the smaller ones, but it may just be the quantities in service. We ran the MTPAV at a place I worked at a few years back and it did OK, but that was back in the 98 days, and the main machine it was on was actually a beige G3 (8 pin serial). I think I had some of the notorious MOTU trouble with it on occasion, maybe more on the PC side of the chain, but I doubted my own experience with such an elaborate setup too much to realize it was actually their fault. ;D
If you want an idea of some of the issues, drink a bunch of cough medicine or something to relax, and then go read this-
http://caps.pcrecruiter.com/MOTU/
It’s old info, and some believe it has been resolved, but many have realized that it hasn’t. I don’t think the guy that wrote it had even run his box for long after whatever driver came out back then, so he probably hadn’t yet hit anything. Although the info is good, and I appreciate the time and knowledge he invested, I still don’t think some of it is a 100% cure. I’ve seen users post of how they got their parallel MOTU box working by a specific, yet convoluted, startup sequence, but I fear they were overly optimistic after seeing it work a few times. Like others, even when I got mine out of “MIDI Flyer” mode, it had the ability to screw up or disappear while it was on the system. I’d almost rather have it go undetected. The SysEx thing mentioned on that site was also a serious problem here, and his suggestion to change channels or something, wasn’t possible with the output of my JLCooper.
It’s a real shame that their software priorities and support are so horrible, especially for those MIDI units, as they have so many nice non-USB ones. The Micro was 4x6 or something, with a pair of front ports, had individual status lights, and was a half rack desktop unit, which probably would have been perfect for what I needed. It worked OK in 98, probably on the Mac as well, so it’s obviously capable “hardware-wise”. I’m keeping it around in hopes that someday they’ll get off their asses and fix some of it, but it doesn’t look promising. They invest far too much in rushing out new hardware and advertising it, so I’m guessing that keeping any previous customers happy isn’t at the top of their list.
If (or when) you start hitting any bumps with it, you may want to write them and make sure they know what’s happening, and are aware of your interest in parallel MIDI and intention of remaining on a PC. That companies priorities and the treatment of it’s customers has really begun to disgust me. When I first gave up on the Micro, I wrote them a nice polite letter explaining most of that, and sent it to customer relations. So far, there’s been nothing, and the support email correspondence ended after the first “try a different cable” type crap response they gave me didn’t work. I’ve taken every opportunity to let people know what the common experiences are with their hardware’s reliability and their poor Windows support. Some are under the impression that it’s changed, but fishing around would prove otherwise.
Here’s another bunch of related comments (most of their MIDI stuff has the same quirks):
http://www.sonicstate.com/digital/comments.cfm?modelid=152&srow=1
and another depressing, but interesting article about some of their company policies:
http://www.soniccontrol.com/blog/index.php?itemid=6
and a somewhat “young” forum (mainly about XP & MOTU’s audio boxes)
http://s15.invisionfree.com/MOTUXP
Then of course there’s UnicorNation, which would probably be more helpful if it’s info were open for unregistered public viewing and would show on search engines.
I’ll probably be seeing you in there. 
Wish you luck with it!
George